中国东北汉族人群补体成分C6、C7和C8（1）的基因多态性

Genetic polymorphism of complement component C6, C7 and C8(1) in Chinese Han population in northeast China.

作者信息

Tsunenari S, Kibayashi K, Higashi T, Pang H, Ding M, Jia J

机构信息

Department of Forensic Medicine, Kumamoto University School of Medicine, Japan.

出版信息

Nihon Hoigaku Zasshi. 1992 Dec;46(6):469-73.

PMID:1303452

Abstract

Distributions of complement phenotypes, C6, C7, and C8(1) were studied using thin agarose gel isoelectric focusing (AGIEF) or ultra-thin polyacrylamide gel isoelectric focusing (PAGIEF) and subsequent immunoblotting techniques in 203 Chinese Han population in Liaoning Province of northeast China. The gene frequencies were as follows: C6A 0.4704, C6B 0.5049, C6B2 0.0148, C6B3 0.0049, and C6M 0.0049; C71 0.8251, C72 0.1108, C73 0.0320, and C7*4 0.0320; C8(1)*A 0.5567 and C8(1)B 0.4433, respectively. All the observed numbers of the phenotypes were in agreement with the expected numbers under the Hardy-Weinberg equilibrium. The gene frequencies among Chinese subpopulations and other various populations were compared.

摘要

在中国东北辽宁省的203名中国汉族人群中，使用薄琼脂糖凝胶等电聚焦（AGIEF）或超薄聚丙烯酰胺凝胶等电聚焦（PAGIEF）以及随后的免疫印迹技术研究了补体表型C6、C7和C8(1)的分布。基因频率如下：C6A 0.4704、C6B 0.5049、C6B2 0.0148、C6B3 0.0049和C6M 0.0049；C71 0.8251、C72 0.1108、C73 0.0320和C7*4 0.0320；C8(1)*A 0.5567和C8(1)B 0.4433。所有观察到的表型数量均与哈迪-温伯格平衡下的预期数量一致。比较了中国亚群和其他不同人群之间的基因频率。