Pelletier J, Habib M, Brouchon M, Poncet M, Lyon-Caen O, Salamon G, Khalil R
Clinique de Neurologie, CHU Timone, Marseille.
Rev Neurol (Paris). 1992;148(11):672-9.
Signs of cerebral disconnection, especially left ear suppression to dichotically presented verbal stimuli, have been reported in multiple sclerosis patients and found to be correlated to morphological atrophy of the corpus callosum on magnetic resonance imaging. To reinvestigate this issue, 26 patients satisfying criteria for definite multiple sclerosis were proposed 3 tasks aimed at evaluating interhemispheric function: a dichotic listening task, a motor finger-tapping task and a sensory transfer task. Performance at these tasks suggested impaired callosal function in MS patients, compared to normal controls. Callosal morphology was assessed on midsagittal MRI sections using a digitalised method of partition of the callosal area into 6 subregions and automatized surface measurements. Results of correlations between task performance and callosal areas showed a significant correlation between total callosal atrophy and severity of interhemispheric impairment on each functional task. Moreover, impaired motor transfer was specifically related to atrophy of the anterior callosal regions. These results suggest that MS patients may constitute a suitable population to studying interhemispheric transfer of information through the callosal commissure and that this approach may be useful in the clinical management of MS patients.
脑连接中断的迹象，尤其是对双耳呈现的言语刺激左耳抑制，在多发性硬化症患者中已有报道，并且发现与磁共振成像中胼胝体的形态萎缩相关。为了重新研究这个问题，对26名符合确诊多发性硬化症标准的患者提出了3项旨在评估半球间功能的任务：双耳分听任务、手指敲击运动任务和感觉传递任务。与正常对照组相比，这些任务的表现表明多发性硬化症患者的胼胝体功能受损。使用将胼胝体区域数字化划分为6个子区域并进行自动表面测量的方法，在矢状面MRI切片上评估胼胝体形态。任务表现与胼胝体区域之间的相关性结果显示，胼胝体总萎缩与每项功能任务中半球间损伤的严重程度之间存在显著相关性。此外，运动传递受损与胼胝体前部区域的萎缩特别相关。这些结果表明，多发性硬化症患者可能是研究通过胼胝体连合进行半球间信息传递的合适人群，并且这种方法可能对多发性硬化症患者的临床管理有用。
