[Detection of G-T mutations at codon 12 of c-Ha-ras oncogenes in squamous cell carcinomas of the sinus maxillaris].

DNA extracted from paraffin-embedded minor carcinoma tissues of the sinus maxillaris, G-T mutations at codon 12 of c-Ha-ras oncogenes were detected with polymerase chain reaction and mutation-specific oligonucleotide probe hybridization, the mutations were identified in 5 out of 20 squamous cell carcinomas of the sinus maxillaris. This result indicated that c-Ha-ras oncogene is one of the genes associated with the development and progression of the squamous cell carcinomas of the sinus maxillaris, and G-T mutation may lead to activation of the c-Ha-ras oncogene.