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[Point mutation of c-Ha-ras oncogene in oral cancers].

作者信息

Liu X F

机构信息

Department of Biochemistry and Molecular Biology, Hubei Medical College.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 1991 Nov;26(6):326-8, 388.

PMID:1820236
Abstract

After sub-sequence of c-Ha-ras oncogene in 11 Chinese oral cancers was amplified with in vitro DNA amplification technique, G----T mutation of c-Ha-ras oncogene at codon 12 was detected by specific mutated oligonucleotide probe, resulting in point mutation of c-Ha-ras oncogene at codon 12 in 4 out of 11 oral cancers which shows that c-Ha-ras oncogene is one of the genes associated with the development and progression of oral cancers, and point mutation may lead to activation of c-Ha-ras oncogene.

摘要

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