Buschmann W
Vormals Universitäts-Augenklinik Würzburg.
Ophthalmologe. 1992 Jun;89(3):237-42.
Some ophthalmic surgeons have preferred N2-cryosurgery for many years. Others feel that only excisional surgery should be used. In this article both possibilities are discussed in an effort to facilitate a well-balanced choice. A total of 262 basalioma patients treated by cryosurgery from 1979 to 1988 were evaluated to assess the indications for cryosurgery. The histological findings were taken into consideration, as were the results of other authors. The comparison with histopathologically controlled excisions was based on discussions with users of the Mohs technique, literature, and personal experience. No other technique permits as much healthy tissue to be saved as N2-cryosurgery; this is especially important in the areas of the lid margin and lacrimal pathways. Complete involvement of the tumor edges can be achieved by generous extension of the treatment area and biopsies taken beyond the expected tumor margins and tumor base (subsequent to tunneling and cryosurgery from the basal side). In excisional surgery, the Mohs technique is required. Its advantage is that biopsies can be taken all around the tumor for histology and its disadvantage is prolonged operation time (in ad hoc frozen sections) or delayed wound closure (second or third surgical procedure several days later). This can be avoided in tumors that are suitable for cryosurgery. The Mohs technique, however, is mandatory in deeply infiltrating tumors in which cryosurgery is not indicated. The two methods complement one another. This is supported by the long-term results.
多年来,一些眼科外科医生更倾向于使用液氮冷冻手术。另一些人则认为仅应采用切除手术。在本文中,将对这两种可能性进行讨论,以便做出权衡得当的选择。对1979年至1988年期间接受冷冻手术治疗的262例基底细胞瘤患者进行了评估,以确定冷冻手术的适应证。评估时考虑了组织学检查结果以及其他作者的研究结果。与组织病理学对照切除的比较基于与莫氏手术使用者的讨论、文献以及个人经验。没有其他技术能像液氮冷冻手术那样保留如此多的健康组织;这在睑缘和泪道区域尤为重要。通过大幅扩大治疗区域以及在预期肿瘤边缘和肿瘤基底之外进行活检(在从基底侧进行隧道式冷冻手术之后),可以实现肿瘤边缘的完全累及。在切除手术中,需要采用莫氏技术。其优点是可以在肿瘤周围各处进行活检以进行组织学检查,其缺点是手术时间延长(在临时冰冻切片时)或伤口闭合延迟(几天后进行第二次或第三次手术)。对于适合冷冻手术的肿瘤,可以避免这种情况。然而,对于不适合冷冻手术的深部浸润性肿瘤,莫氏技术是必不可少的。这两种方法相辅相成。长期结果也证实了这一点。