[选择性H1拮抗剂氯雷他定（LO）对组胺诱导的支气管收缩的影响]
[Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction].
作者信息
Grzelewska-Rzymowska I, Gondorowicz K, Cieślewicz G, Rozniecki J, Wojciechowska B
机构信息
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
出版信息
Pneumonol Alergol Pol. 1992;60(11-12):16-21.
The influence of single and repeated LO (10 mg/day) doses on histamine-induced bronchoconstriction was studied in 11 patients with stabile bronchial asthma. Bronchial reactivity was estimated as histamine content potent to elicit a 20% FEV, fall, i.e. PC20H. A single dose gave a significant (5.5 fold) reduction in bronchial reactivity to inhaled histamine. Application of LO during 6 days gave a similar effect. Withdrawal of LO for 6 days yielded an increase in bronchial hyperreactivity.
在11例稳定期支气管哮喘患者中研究了单次和重复给予洛哌丁胺（10毫克/天）剂量对组胺诱导的支气管收缩的影响。支气管反应性通过引起FEV₁下降20%的组胺含量来评估，即PC20H。单次给药使对吸入组胺的支气管反应性显著降低（5.5倍）。连续6天给予洛哌丁胺产生了类似的效果。停用洛哌丁胺6天后，支气管高反应性增加。
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