Gendrel D, Chemillier-Truong M, Rodrigue D, Bosco O, Specker I, Raymond J, Saliou P, Lebon P
Département de Pédiatrie, Hôpital Saint-Vincent-de-Paul, Paris.
Arch Fr Pediatr. 1992 Dec;49(10):865-8.
Measles remains prevalent in France despite the development of nationwide vaccination program. This study evaluates measles immunity and correlates it with active immunization.
A total of 250 (131 boys and 119 girls) French children, aged 2 to 15 years, seen as outpatients in our hospital, were studied from 1.01.90 to 1.06.91; 133 had received live measles vaccine during the 2nd year of life, the 117 others were not vaccine-protected. Evaluation included medical records, specially those concerning past-history of measles or measles-like diseases and immunizations. Measles IgG and IgM antibodies (ELISA) were looked for in all 250 children.
102 of the 117 children who were not vaccine-protected had a detectable antibody titer. 42 of these 102 had a history of measles, before the age of 5 years in 30, between 5 and 10 years in 9 and after the age of 10 years in 3. Only 4 of the 70 children aged over 10 years and not vaccine-protected had no detectable antibodies. 131 of the 133 actively immunized children had detectable antibodies.
Measles is probably more frequently subclinical than was believed until now. Its relative frequency in France in children who had not received the live vaccine explains the high percentage of those aged over 10 years who had detectable antibodies and the relatively low incidence of the disease in teenagers and young adults.
尽管法国开展了全国性的疫苗接种计划，但麻疹在该国仍很普遍。本研究评估了麻疹免疫力，并将其与主动免疫相关联。
1990年1月1日至1991年6月1日期间，对我院门诊就诊的250名（131名男孩和119名女孩）2至15岁的法国儿童进行了研究；其中133名儿童在生命的第二年接种了麻疹活疫苗，另外117名未接种疫苗。评估包括病历，特别是那些关于麻疹或麻疹样疾病的既往史以及免疫接种情况。对所有250名儿童检测了麻疹IgG和IgM抗体（酶联免疫吸附测定）。
117名未接种疫苗的儿童中有102名可检测到抗体滴度。这102名儿童中有42名有麻疹病史，其中30名在5岁前，9名在5至10岁之间，3名在10岁后。10岁以上未接种疫苗的70名儿童中只有4名未检测到抗体。133名主动免疫的儿童中有131名可检测到抗体。
麻疹可能比目前认为的更常为亚临床感染。在法国未接种活疫苗的儿童中其相对发生率解释了10岁以上可检测到抗体的儿童比例较高以及青少年和年轻人中该病发病率相对较低的原因。
