Pedespan J M, Fontan D, Perel Y, Guérin J, Guillard J M
Service de Pédiatrie B et de Neurochirurgie, Hôpital Pellegrin, Bordeaux.
Arch Fr Pediatr. 1992 Dec;49(10):887-9.
Infantile spasms are exceptionally associated with a focal cerebral lesion such as a brain tumor.
A 15 month-old girl was treated with hydrocortisone and valproic acid for infantile spasms that had appeared a few days earlier. Her psychomotor development was considered normal and the CT scan was normal. Clinical symptoms disappeared within 10 days and the EEG became normal except for a few epileptiform discharges in the frontal areas. The girl developed partial seizures at the age of 5 years. Imaging techniques showed a brain tumor in the right frontal lobe. Surgical excision was followed by radiation therapy. Analysis of the tumor showed an astrocytoma. The girl is normal 18 months after intervention.
It is difficult to determine a relationship between the infantile spasms and the brain tumor in this case. The moderately asymmetrical pattern of the EEG after infantile spasms, the fact that these spasms appeared relatively late and the persistence of discharges, lead to repeated specialized investigations.
婴儿痉挛症与诸如脑肿瘤等局灶性脑病变异常相关。
一名15个月大的女孩因数天前出现的婴儿痉挛症接受了氢化可的松和丙戊酸治疗。她的精神运动发育被认为正常，CT扫描也正常。临床症状在10天内消失，脑电图除额叶有少量癫痫样放电外恢复正常。该女孩在5岁时出现部分性癫痫发作。影像学检查显示右额叶有一个脑肿瘤。手术切除后进行了放射治疗。肿瘤分析显示为星形细胞瘤。干预18个月后女孩情况正常。
在该病例中难以确定婴儿痉挛症与脑肿瘤之间的关系。婴儿痉挛症后脑电图呈中度不对称模式，这些痉挛出现相对较晚且放电持续存在，导致反复进行专业检查。
