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体外细胞介导的免疫反应。I. 混合淋巴细胞培养中抑制细胞和细胞毒性淋巴细胞的发育。

Cell-mediated immune response in vitro. I. The development of suppressor cells and cytotoxic lymphocytes in mixed lymphocyte cultures.

作者信息

Hirano T, Nordin A A

出版信息

J Immunol. 1976 Apr;116(4):1115-22.

PMID:130426
Abstract

During the in vitro development of cytotoxic lymphocytes (CL), suppressor cells also develop. Spleen cells or lymph node cells harvested from mixed lymphocyte cultures (MLC) on day 2 (day-2 MLC) and added to a fresh MLC suppressed the development of CL. This suppressive effect was sensitive to treatment with anti-theta and C. The suppressive effect of day-2 MLC was not due to cytotoxic effects nor to altered kinetics of the development of both suppressor cells and CL. Although CL develop from hydrocortisone-treated spleen cells, day-2 MLC of hydrocortisone-treated spleen cells did not suppress the development of CL. These studies suggest that suppressor cells and CL are derived from different T cell subpopulations.

摘要

在细胞毒性淋巴细胞（CL）的体外发育过程中，抑制细胞也会发育。从第2天的混合淋巴细胞培养物（MLC）（第2天MLC）中收获的脾细胞或淋巴结细胞，并添加到新鲜的MLC中，可抑制CL的发育。这种抑制作用对抗θ处理和补体敏感。第2天MLC的抑制作用既不是由于细胞毒性作用，也不是由于抑制细胞和CL发育动力学的改变。虽然CL由氢化可的松处理的脾细胞发育而来，但氢化可的松处理的脾细胞的第2天MLC并未抑制CL的发育。这些研究表明，抑制细胞和CL源自不同的T细胞亚群。

相似文献

1
Cell-mediated immune response in vitro. I. The development of suppressor cells and cytotoxic lymphocytes in mixed lymphocyte cultures.体外细胞介导的免疫反应。I. 混合淋巴细胞培养中抑制细胞和细胞毒性淋巴细胞的发育。
J Immunol. 1976 Apr;116(4):1115-22.
2
Cell-mediated immune response in vitro. II. The mechanism(s) involved in the suppression of the development of cytotoxic lymphocytes.体外细胞介导的免疫反应。II. 细胞毒性淋巴细胞发育抑制所涉及的机制。
J Immunol. 1976 Dec;117(6):2226-32.
3
Generation of cytotoxic T lymphocytes in vitro. VII. Suppressive effect of irradiated MLC cells on CTL response.体外细胞毒性T淋巴细胞的产生。VII. 经辐照的混合淋巴细胞培养细胞对细胞毒性T淋巴细胞反应的抑制作用。
J Immunol. 1976 Mar;116(3):716-23.
4
Generation of cytotoxic T lymphocytes in vitro. VI. Effect of cell density on response in mixed leukocyte cultures.体外细胞毒性T淋巴细胞的产生。VI. 细胞密度对混合淋巴细胞培养反应的影响。
J Immunol. 1975 Dec;115(6):1688-94.
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Cell-mediated immune responses in vitro. III. Elimination of specific cytotoxic lymphocyte responses by 3H-thymidine suicide.体外细胞介导的免疫反应。III. 用³H-胸腺嘧啶核苷自杀法消除特异性细胞毒性淋巴细胞反应。
J Immunol. 1975 Dec;115(6):1521-4.
6
Suppression of cytotoxic lymphocyte responses in vitro by soluble products of alloantigen-activated spleen cells.同种异体抗原激活的脾细胞可溶性产物对体外细胞毒性淋巴细胞反应的抑制作用。
J Immunol. 1978 Sep;121(3):1045-51.
7
[Suppressor cells in the "in vitro" induced cell mediated immune response: their origin and target (author's transl)].["体外"诱导的细胞介导免疫反应中的抑制细胞：其起源与靶细胞（作者译）]
Ann Immunol (Paris). 1977 Jul-Oct;128C(4-5):915-7.
8
Interaction between T cells and non-T cells in suppression of cytotoxic lymphocyte responses.T细胞与非T细胞在抑制细胞毒性淋巴细胞反应中的相互作用。
J Immunol. 1979 Aug;123(2):745-50.
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Fractionation of lymphocyte subpopulations which regulate mixed lymphocyte reactions.调节混合淋巴细胞反应的淋巴细胞亚群的分离。
J Immunol. 1977 Apr;118(4):1252-8.
10
T cells in mixed-lymphocyte-culture-induced cytolysis (MLC-CML).混合淋巴细胞培养诱导的细胞溶解（MLC-CML）中的T细胞
Transplant Proc. 1973 Dec;5(4):1697-703.

引用本文的文献

1
Recognition of polymorphic H-2 domains by T lymphocytes. I. Functional role of different H-2 domains for the generation of alloreactive cytotoxic T lymphocytes and determination of precursor frequencies.T淋巴细胞对多态性H-2结构域的识别。I. 不同H-2结构域在同种异体反应性细胞毒性T淋巴细胞生成中的功能作用及前体细胞频率的测定。
J Exp Med. 1981 Dec 1;154(6):1717-31. doi: 10.1084/jem.154.6.1717.
2
Quantitative studies on T cell diversity. II. Determination of the frequencies and Lyt phenotypes of two types of precursor cells for alloreactive cytotoxic T cells in polyclonally and specifically activated splenic T cells.T细胞多样性的定量研究。II. 多克隆和特异性激活的脾T细胞中同种异体反应性细胞毒性T细胞两种前体细胞的频率及Lyt表型的测定
J Exp Med. 1981 Apr 1;153(4):857-70. doi: 10.1084/jem.153.4.857.
3
[Immunologic specificity, nature and properties of suppressor cells induced in mixed lymphocyte cultures].[混合淋巴细胞培养中诱导产生的抑制细胞的免疫特异性、性质和特性]
Biull Eksp Biol Med. 1980 Mar;89(3):315-8. doi: 10.1007/BF00834238.
4
The induction of suppressor cells in mixed leucocyte cultures and in mixed leucocyte-non-lymphoid cell cultures.混合白细胞培养物和混合白细胞-非淋巴细胞培养物中抑制细胞的诱导。
Immunology. 1980 Jan;39(1):11-20.
5
Humoral inhibitors of the immune response in uremia. V. Induction of suppressor cells in vitro by uremic serum.尿毒症中免疫反应的体液抑制剂。V. 尿毒症血清在体外诱导抑制细胞
Am J Pathol. 1983 May;111(2):149-55.
6
The in vitro generation of suppressor lymphocytes involves interactions between PNA+ and PNA- thymocyte populations.抑制性淋巴细胞的体外生成涉及PNA⁺和PNA⁻胸腺细胞群体之间的相互作用。
Immunology. 1982 Aug;46(4):697-704.
7
Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation.接受全身淋巴照射的成年小鼠或新生小鼠的脾细胞在混合淋巴细胞反应中具有相似的调节作用。一、在加入接受全身淋巴照射的成年小鼠脾细胞后，混合淋巴细胞反应中抗原特异性抑制细胞的产生。
J Exp Med. 1982 Aug 1;156(2):522-38. doi: 10.1084/jem.156.2.522.
8
T cell subsets participating in the generation of cytotoxic T cells.参与细胞毒性T细胞生成的T细胞亚群。
Springer Semin Immunopathol. 1980 May;3(1):39-62. doi: 10.1007/BF00199925.
9
Cancer chemotherapeutics as immunomodulators.作为免疫调节剂的癌症化疗药物。
Springer Semin Immunopathol. 1985;8(4):361-74. doi: 10.1007/BF01857390.
10
Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer.胸腺细胞介导的器官同种异体移植特异性无反应性的转移。胸腺细胞转移导致的特异性无反应性。
J Exp Med. 1979 May 1;149(5):1042-55. doi: 10.1084/jem.149.5.1042.