Savel'ev S V, Chernikov V P
Izv Akad Nauk Ser Biol. 1992 May-Jun(3):465-71.
Human embryos with anomalies of brain and spinal cord were studied on 27-35th day of the development. It was established that developmental anomalies were associated with the disturbed formation of neural tube. The reconstruction of three-dimensional brain arrangement of embryos has shown the presence of different variants of nonclosed medullar tori. In mild disturbance of neurulation, there is an acceleration of organogenesis and morphological differentiation induced by the shackening of normal mechanical tensions and relaxation of neuroepithelial layers. In presence of substantial parts of open neural tube, the development of brain and ectodermal derivatives becomes disturbed to be a possible cause of anencephaly and hypotelorism. The type of disturbed neurulation inducing developmental anomalies of nervous system is suggested to be a factor which determines forms of secondary craniofacial and cranial pathology.
对发育第27至35天的伴有脑和脊髓异常的人类胚胎进行了研究。已确定发育异常与神经管形成紊乱有关。胚胎三维脑结构的重建显示存在不同类型的未闭合髓质环。在神经胚形成的轻度紊乱中，正常机械张力的改变和神经上皮层的松弛会导致器官发生和形态分化加速。在存在大部分开放神经管的情况下，脑和外胚层衍生物的发育会受到干扰，这可能是无脑畸形和眼距过窄的原因。神经胚形成紊乱导致神经系统发育异常的类型被认为是决定继发性颅面和颅骨病理形式的一个因素。
