Daly M, Seay J, Balshem A, Lerman C, Engstrom P
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19012.
Cancer Epidemiol Biomarkers Prev. 1992 Jul-Aug;1(5):413-6.
A large-scale, nationwide tamoxifen chemoprevention trial is currently being planned as a primary preventive strategy against breast cancer. The recruitment of health asymptomatic women into a long-term clinical trial will pose unique recruitment problems. This study examines the feasibility of telephone recruitment from a health maintenance organization population into such a trial. A random sample of 203 women aged 50 and older with a personal family history of breast cancer were contacted by telephone. A structured interview was administered to assess self-perceived risk of breast cancer, willingness to participate in a trial, and anticipated barriers to participation. Of the 203 names generated from the health maintenance organization membership roster 128 (63%) met eligibility criteria and participated in the interview. Forty-five % of the eligible women expressed interest in the tamoxifen trial. Women who felt that their family would support their participation expressed significantly more interest, while concern about possible side effects emerged as potential barriers. We conclude that contact by telephone among health maintenance organization members can identify a significant proportion of women who are interested in primary chemoprevention for breast cancer. Participation rates may be improved by bolstering family support and by addressing concerns about drug toxicity.
一项大规模的全国性他莫昔芬化学预防试验目前正在规划中，作为预防乳腺癌的主要策略。招募健康无症状女性参与长期临床试验将带来独特的招募问题。本研究探讨了从健康维护组织人群中通过电话招募参与此类试验的可行性。通过电话联系了203名年龄在50岁及以上且有乳腺癌个人家族史的女性随机样本。进行了结构化访谈，以评估自我感知的乳腺癌风险、参与试验的意愿以及预期的参与障碍。从健康维护组织成员名册中生成的203个名字中，128名（63%）符合资格标准并参与了访谈。45%的符合条件的女性对他莫昔芬试验表示感兴趣。认为家人会支持其参与的女性表现出明显更高的兴趣，而对可能的副作用的担忧成为潜在障碍。我们得出结论，通过电话联系健康维护组织成员可以识别出相当比例的对乳腺癌一级化学预防感兴趣的女性。通过加强家庭支持和解决对药物毒性的担忧，参与率可能会提高。
