Koss L G
Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467.
J Cell Biochem Suppl. 1992;16I:23-9. doi: 10.1002/jcb.240501305.
The key events leading to a better understanding of the natural history of urothelial tumors of the bladder are summarized. These were: the recognition of flat carcinoma in situ and related lesions (intraurothelial neoplasia) as principal sources of invasive cancer; identification of the unique structure of the urothelium; analysis of DNA content and the recognition of two pathways of urothelial tumors. A brief comment on the current status of immunologic and molecular genetic markers is appended.
本文总结了有助于更好地理解膀胱尿路上皮肿瘤自然史的关键事件。这些事件包括：认识到原位扁平癌及相关病变（尿路上皮内瘤变）是浸润性癌的主要来源；确定尿路上皮的独特结构；分析DNA含量以及认识尿路上皮肿瘤的两条发展途径。文末还对免疫和分子遗传标志物的现状作了简要评论。
