Pecelj-Gec M, Jorga J, Marmut Z, Plećas D, Mirić G
Dietetic Department, Institute of Hygiene and Medical Ecology, School of Medicine, Belgrade.
Srp Arh Celok Lek. 1992 Sep-Oct;120(9-10):273-5.
Since the evidence to data suggest that some obese person respond well to non-pharmacological measures, the aim of this study was to examine the extent of body weight reduction necessary to reduce blood pressure to normal values. A group of 250 obese women with hypertension (blood pressure measurements over 160/95) and an overweight of at least 20 per cent excess of ideal weight was included in the study. The patients were advised to take well balanced low-calorie (about 1000 kcal/day) diet containing 66 g proteins, 140 g carbohydrates, 13 g fat and 0.5 g salt. They were advised to increase daily physical activities. Low-calorie diets were used to decrease body weight in groups of patients with changed of unchanged antihypertensive drug therapy, also. Decrease in body weight resulted in significant decrease in blood pressure; over two-thirds of complaint patients achieve normal blood pressure with a loss of only 5-10 per cent of their weight excess even if at this point they were still overweight. In the group receiving no drug therapy 78 per cent reached normal blood pressure, 76 per cent in the patients whose antihypertensive treatment had to be modified during the study and 63 per cent in the group receiving unchanged drug therapy. It was concluded that weight reduction program (diet and physical activity) can be a possible approach to treat hypertension without drugs and patients can attain normotension long before achieving the ideal weight.
由于现有证据表明,一些肥胖者对非药物治疗措施反应良好,本研究旨在探讨将血压降至正常水平所需的体重减轻程度。该研究纳入了250名患有高血压(血压测量值超过160/95)且超重至少20%(超过理想体重)的肥胖女性。建议患者采用营养均衡的低热量饮食(约1000千卡/天),其中包含66克蛋白质、140克碳水化合物、13克脂肪和0.5克盐。建议她们增加日常身体活动。低热量饮食也用于在改变或未改变抗高血压药物治疗的患者组中减轻体重。体重减轻导致血压显著下降;超过三分之二的患者即使此时仍超重,但仅减轻其超重体重的5% - 10%就达到了正常血压。在未接受药物治疗的组中,78%的患者血压恢复正常;在研究期间必须调整抗高血压治疗的患者中,这一比例为76%;在接受未改变药物治疗的组中,这一比例为63%。研究得出结论,减重计划(饮食和身体活动)可能是一种无需药物治疗高血压的方法,患者在达到理想体重之前很久就能实现血压正常。