宫城县神经母细胞瘤大规模筛查。

Mass screening for neuroblastoma in Miyagi Prefecture.

作者信息

Itano M, Morita S, Fujie H, Ohashi Y, Minegishi N, Minegishi M, Yamaguchi Y, Sato T, Tsuchiya S, Konno T

机构信息

Department of Pediatrics, Tohoku University, Sendai, Japan.

出版信息

Tohoku J Exp Med. 1992 Oct;168(2):137-9. doi: 10.1620/tjem.168.137.

DOI:10.1620/tjem.168.137

PMID:1306297

Abstract

In Japan, aiming at early and preclinical detection of neuroblastoma in infancy a mass screening program for the tumor has been implemented nationwide using urinary tests for catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA) (Sawada 1990; Sawada et al. 1991). In this report, the results obtained from the screening program in Miyagi Prefecture for the last 6 years are described. The detection rate of neuroblastoma by mass screening was 1:8,377 among 125,652 infants tested in Miyagi Prefecture. All but one patients survived after removal of the primary tumor and none or minimal chemotherapy.

摘要

在日本，为了在婴儿期早期和临床前检测神经母细胞瘤，已在全国范围内实施了针对该肿瘤的大规模筛查计划，使用尿液检测儿茶酚胺代谢物香草扁桃酸（VMA）和高香草酸（HVA）（泽田，1990年；泽田等人，1991年）。在本报告中，描述了宫城县过去6年筛查计划的结果。在宫城县接受检测的125,652名婴儿中，通过大规模筛查检测到神经母细胞瘤的比率为1:8,377。除一名患者外，所有患者在切除原发性肿瘤后存活，且未进行化疗或仅进行了极少的化疗。