Nataf P, Gandjbakhch I, Pavie A, Bors V, Dorent R, Vaissier E, Levasseur J P, Leger P, Cabrol A, Cabrol C
Department of Cardiovascular Surgery, Hôpital de la Pitié, Paris, France.
Clin Transpl. 1992:129-35.
Clinical application of heart transplantation goes beyond 25 years experience. The main indications for cardiac transplantation remain idiopathic cardiomyopathies and ischemic diseases. To obtain a suitable donor has become progressively more difficult due to the increase of transplants performed and the shortage of donors. Advances in the detection of early rejection, improved organ preservation procedures, and the introduction of new immunosuppressive therapy protocols have produced dramatic results in heart transplantation. Late graft atherosclerosis remains a serious threat despite retransplantation and, in some cases, mechanical cardiac support.
心脏移植的临床应用已有超过25年的经验。心脏移植的主要适应症仍然是特发性心肌病和缺血性疾病。由于心脏移植手术数量的增加以及供体的短缺，获取合适的供体变得越来越困难。早期排斥反应检测技术的进步、器官保存程序的改进以及新免疫抑制治疗方案的引入，在心脏移植领域取得了显著成效。尽管进行了再次移植，并且在某些情况下采用了机械心脏支持，但晚期移植血管粥样硬化仍然是一个严重威胁。
