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无预防性抗淋巴细胞制剂的免疫抑制。

Immunosuppression without prophylactic antilymphocyte preparations.

作者信息

Pfaff W W, Patton P R, Howard R J, Brunson M E, Ramos E L, Fennell R S, Peterson J C, Scornik J C

机构信息

Department of Surgery, University of Florida College of Medicine, Gainesville.

出版信息

Clin Transpl. 1992:237-48.

PMID:1306702
Abstract
  1. Triple-drug immunosuppression following third party transfusion can result in graft survival equal to protocols that employ prophylactic antilymphocyte preparations. 2. T1/2 was statistically improved in cadaveric and living-related donor grafts in the CsA era. 3. Patients 65 years and older had an excessive death rate. Younger groups were admixed. Extreme youth was not a risk factor. 4. Black recipients had excessive late graft loss. 5. Diabetic recipients had only a slight decline in graft and patient survival rates. 6. First and multiple graft recipients had similar transplant survival rates. 7. Delayed graft function remains costly in this immunosuppressive scheme.
摘要
  1. 接受第三方输血后的三联免疫抑制可使移植物存活率与采用预防性抗淋巴细胞制剂的方案相当。2. 在环孢素A时代,尸体供体和亲属活体供体移植物的半衰期在统计学上有所改善。3. 65岁及以上患者的死亡率过高。各年轻组混杂在一起。极端年轻不是一个风险因素。4. 黑人受者后期移植物丢失过多。5. 糖尿病受者的移植物和患者存活率仅略有下降。6. 首次移植和多次移植受者的移植存活率相似。7. 在这种免疫抑制方案中,移植功能延迟的成本仍然很高。

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