Strolin Benedetti M, Dostert P, Tipton K F
Farmitalia Carlo Erba, R&D-Erbamont Group, Milan, Italy.
Dev Pharmacol Ther. 1992;18(3-4):191-200.
In the rat heart, monoamine oxidase (MAO)-B activity was shown to predominate in 2- to 3-week-old animals, whereas MAO-A activity was reported to be very low in newborn rats and to increase considerably with age until it predominates. These results are in contrast with those found in the mouse heart, where an age-dependent increase in MAO-B activity with no changes in 5-hydroxytryptamine deaminating activity was found to occur. There is evidence that the adult values of MAO activity are reached early in development in rat kidney and liver. In the rat lung the adult values of MAO-A activity are reached by day 40, whereas MAO-B activity is still increasing by day 80. Important differences have been reported in the developmental pattern of the two forms of MAO in the rat and mouse brain, with a decrease in the MAO-A/MAO-B ratio during postnatal development. In the human brain, the ontogenetic development of MAO-A and MAO-B appears to parallel that observed in the rodent brain. It is worth noting that most of the available data have to be considered with reservation owing to many methodological problems. Further studies are clearly needed to get reliable information on the ontogenesis of MAO in mammalian tissues.
在大鼠心脏中，单胺氧化酶（MAO）-B活性在2至3周龄的动物中占主导地位，而据报道，MAO-A活性在新生大鼠中非常低，并随着年龄的增长而显著增加，直至占主导地位。这些结果与在小鼠心脏中发现的结果相反，在小鼠心脏中，发现MAO-B活性随年龄增长而增加，而5-羟色胺脱氨基活性没有变化。有证据表明，大鼠肾脏和肝脏在发育早期就达到了MAO活性的成年值。在大鼠肺中，MAO-A活性在第40天达到成年值，而MAO-B活性在第80天仍在增加。据报道，大鼠和小鼠大脑中两种形式的MAO的发育模式存在重要差异，出生后发育过程中MAO-A/MAO-B比值降低。在人类大脑中，MAO-A和MAO-B的个体发生发育似乎与在啮齿动物大脑中观察到的情况相似。值得注意的是，由于许多方法学问题，大部分现有数据都必须谨慎对待。显然需要进一步的研究来获得关于哺乳动物组织中MAO个体发生的可靠信息。
