Huang W M
Shanghai Xu Hui District Central Hospital.
Zhonghua Xin Xue Guan Bing Za Zhi. 1992 Oct;20(5):310-2, 325.
The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action.
采用双微电极电压钳技术研究了黄连素（0.1 - 10毫克/升）对犬浦肯野纤维延迟激活钾电流（iK）的影响。黄连素（Ber）以浓度依赖性方式显著降低iK的幅度。当用10毫克/升黄连素灌注时，浦肯野纤维的尾电流幅度立即下降，抑制率为73.6 +/- 4.5%（n = 9，P < 0.001）。黄连素对iK的抑制作用可能解释了其对动作电位时程的延长作用及其抗心律失常作用。
