TYRRELL D A
J Exp Med. 1953 Jun;97(6):863-70. doi: 10.1084/jem.97.6.863.
On the assumption that antibody is added to virus particles in a stepwise manner and that the reaction follows the law of mass action, a theoretical equation for the equilibrium state of virus neutralization reactions has been deduced. The theory has been found to be in reasonable accord with the available data for the neutralization of bacterial viruses and can be applied also to data for the neutralization of animal viruses.
假设抗体以逐步方式添加到病毒颗粒中,且反应遵循质量作用定律,由此推导出了病毒中和反应平衡状态的理论方程。现已发现该理论与细菌病毒中和的现有数据相当吻合,并且也可应用于动物病毒中和的数据。