Leite N C, Nogueira C M, Coelho H S, Perez R, Martins S J, Soares J A, Junqueira P C
Serviço de Clínica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro.
Arq Gastroenterol. 1992 Jan-Mar;29(1):5-11.
We have studied 933 volunteer blood donors from May to July, 1990. After a interview and screening tests for syphilis, Chagas disease, malaria and HIV, they underwent an enzyme immunoassay for HBsAg, anti HBc and anti HCV antibodies. Alanine aminotransferase (ALT) serum levels were determined by auto analyser. Most blood donors were male with mean age of 33 years (19-65). Anti HCV prevalence was 3.1% (29 from 933 blood donors). Among anti HCV+, blood donors, 44.8% (13/29) had ALT 40 UI/L, 31% (9/29) were anti HBc+ and 17.2% (5/29) had both surrogate markers simultaneously. From 109 donors with ALT 40 UI/L, 13 (11.9%) were anti HCV+, while among 153 anti HBc+ donors, the anti HCV was 5.8%.
我们在1990年5月至7月期间研究了933名自愿献血者。在对他们进行梅毒、恰加斯病、疟疾和艾滋病毒的访谈及筛查检测后，对其进行了乙肝表面抗原、乙肝核心抗体和丙肝抗体的酶免疫测定。通过自动分析仪测定血清丙氨酸转氨酶（ALT）水平。大多数献血者为男性，平均年龄33岁（19 - 65岁）。丙肝抗体阳性率为3.1%（933名献血者中有29名）。在丙肝抗体阳性的献血者中，44.8%（13/29）的ALT≥40 UI/L，31%（9/29）乙肝核心抗体阳性，17.2%（5/29）同时具有这两种替代标志物。在ALT≥40 UI/L的109名献血者中，13名（11.9%）丙肝抗体阳性，而在153名乙肝核心抗体阳性的献血者中，丙肝抗体阳性率为5.8%。
1）我们发现我们的献血者中丙肝抗体阳性率高于其他国家先前发表的报告；2）我们的数据表明替代检测不能充分识别丙肝抗体阳性的献血者，仅靠乙肝核心抗体和ALT检测，41.4%的此类献血者不会被排除；3）丙肝抗体阳性且样本与临界光密度比值等于或大于4与血清ALT水平升高之间存在相关性。
