Zhang Z H
Peking Union Medical College Hospital, Beijing.
Zhonghua Wai Ke Za Zhi. 1992 Aug;30(8):478-80, 509.
36 cases of carcinoid of the digestive tract were presented. The malignancy of the carcinoid was established solely by the presence of local infiltration and remote metastasis irrespective of the size of the original tumor three of 10 cases of the tumor less than 2 cm in diameter had metastasis although smaller tumors were usually benign. Immuno-histochemistry study in 15 cases showed 1-4 kinds of different polypeptides in each case. Three of 8 cases of malignant carcinoid syndrome had normal blood level of 5-HT and 5-HIAA, suggesting other polypeptides as the cause of the syndrome. The absence of hepatic metastasis in 4 of the 8 cases favors the hypothesis that polypeptides may get access to the general circulation by such as retroperitoneal pathways.
本文报告了36例消化道类癌。类癌的恶性程度仅由局部浸润和远处转移来确定，而与原发肿瘤的大小无关，10例直径小于2cm的肿瘤中有3例发生了转移，尽管较小的肿瘤通常为良性。15例免疫组织化学研究显示，每例中有1 - 4种不同的多肽。8例恶性类癌综合征患者中有3例5 - HT和5 - HIAA的血液水平正常，提示其他多肽可能是该综合征的病因。8例中有4例无肝转移，这支持了多肽可能通过腹膜后途径等进入体循环的假说。
