用肾上腺皮质类固醇处理对不同年龄大鼠对氨基马尿酸肾小管转运的刺激作用。
Stimulation of renal tubular transport of p-aminohippurate in rats of different ages by treatment with adrenocortical steroids.
作者信息
Bräunlich H, Rassbach H, Vogelsang S
机构信息
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, FRG.
出版信息
Dev Pharmacol Ther. 1992;19(1):1-5. doi: 10.1159/000457455.
PMID:1307340
Abstract
Treatment with prednisolone or dexamethasone is followed by an increase in renal excretion of p-aminohippurate (PAH) and in accumulation of PAH in renal cortical slices, particularly in 5- and 10-day-old rats with immature kidney function. Treatment with triamcinolone is effective both in immature and in 55-day-old rats. There is no stimulation of PAH transport after treatment with mineralocorticoids (desoxycorticosterone, aldosterone).
摘要
用泼尼松龙或地塞米松治疗后，对氨基马尿酸（PAH）的肾排泄增加，且PAH在肾皮质切片中的蓄积增加，尤其在5日龄和10日龄肾功能未成熟的大鼠中。用曲安西龙治疗对未成熟大鼠和55日龄大鼠均有效。用盐皮质激素（脱氧皮质酮、醛固酮）治疗后，PAH转运未受刺激。
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