Bräunlich H, Köhler A, Schmidt I
Med Biol. 1986;64(5):267-70.
In 5-, 10- and 15-day-old rats repeated administration of dexamethasone caused a dose-dependent increase of p-aminohippurate (PAH) excretion. Remarkably, dexamethasone has no influence on PAH excretion in adult rats. The effect of treatment in young rats cannot be explained by an increase in the glomerular filtration rate. In 10-day-old rats GFR shows a tendency to increase. In renal cortical slices from 5-day-old rats PAH transport is increased following dexamethasone treatment, whereas in 10- and 15-day-old rats an increase of kidney mass seems to be responsible for acceleration of renal excretion of PAH after administration of dexamethasone. In 5-day-old rats only the protein content is statistically significantly increased after dexamethasone treatment.
在5日龄、10日龄和15日龄的大鼠中，重复给予地塞米松会导致对氨基马尿酸（PAH）排泄呈剂量依赖性增加。值得注意的是，地塞米松对成年大鼠的PAH排泄没有影响。幼鼠中治疗的效果无法用肾小球滤过率的增加来解释。在10日龄大鼠中，肾小球滤过率有增加的趋势。在5日龄大鼠的肾皮质切片中，地塞米松治疗后PAH转运增加，而在10日龄和15日龄大鼠中，肾脏重量的增加似乎是地塞米松给药后PAH肾排泄加速的原因。在5日龄大鼠中，地塞米松治疗后仅蛋白质含量有统计学显著增加。
