de Almeida E A, Martin C B, Teixeira M A, Carvalhal S dos S
Grupo de Estudo de Doença de Chagas, GEDOCH, UNICAMP, PUCCAMP.
Arq Bras Cardiol. 1992 Feb;58(2):91-4.
Studying the mitral valve in chronic Chagas' heart disease, searching a possible cause effect relationship between this condition and valve prolapse.
Seventeen hearts were surveyed from individuals exhibiting chronic chagasic cardiopathy, 11 males and 6 females, aged between 31-84 (average 54) years. The hearts came from necropsies carried out until a year before. Properly preserved samples were analyzed macro and microscopically. Fragments were excised from the mitral valve papillary muscles, anterior, lateral and posterior regions of the left ventricle, interventricular septum, free wall of right ventricle and atrium walls.
Chronic myocarditis was found ill all the samples (mild in 6 of them, moderate in 7 and severe in 4). Also, the papillary muscles exhibited myocarditis in all of the samples, and in 15 of them the degree of severity was equal to or superior than the observed in degree other regions of the heart.
The chronic chagasic cardiopathy, the papillary muscle constitute a frequent site of myocarditis. This fact must be held in mind when one discusses the pathogenesis of the prolapse of the valve.
研究慢性恰加斯心脏病中的二尖瓣，探寻这种疾病与瓣膜脱垂之间可能的因果关系。
对17例患有慢性恰加斯心肌病的个体的心脏进行检查，其中男性11例，女性6例，年龄在31 - 84岁（平均54岁）之间。这些心脏取自直至一年前进行的尸检。对妥善保存的样本进行宏观和微观分析。从二尖瓣乳头肌、左心室前壁、侧壁和后壁、室间隔、右心室游离壁和心房壁切取组织块。
在所有样本中均发现慢性心肌炎（6例为轻度，7例为中度，4例为重度）。此外，所有样本中的乳头肌均出现心肌炎，其中15例的严重程度等于或高于心脏其他区域观察到的程度。
在慢性恰加斯心脏病中，乳头肌是心肌炎的常见部位。在讨论瓣膜脱垂的发病机制时必须牢记这一事实。
