Sobaniec W
Department of Neurology, Medical Academy, Białystok, Poland.
Mater Med Pol. 1992 Apr-Jun;24(2):115-9.
The serum valproate (VPA) concentration and the clinical effects of polytherapy with other antiepileptic drugs: phenobarbital (PB), clonazepam (CZP), diazepam (DZ), clobazam (CLO), ethosuximide (ESX) were estimated. VPA serum levels were reduced when this drug was combined with phenobarbital. Clobazam given together with valproate led to an increase in the serum concentration of the former drug. VPA serum levels were without significant changes when the drug was combined with either ethosuximide or 1-4-benzodiazepines. The best therapeutical effects were found after polytherapy sodium valproate with ethosuximide and clobazam in primary generalized seizures.
评估了丙戊酸盐（VPA）血清浓度以及丙戊酸盐与其他抗癫痫药物联合治疗的临床效果：苯巴比妥（PB）、氯硝西泮（CZP）、地西泮（DZ）、氯巴占（CLO）、乙琥胺（ESX）。当丙戊酸盐与苯巴比妥联合使用时，其血清水平降低。氯巴占与丙戊酸盐一起使用会导致前者药物血清浓度升高。当丙戊酸盐与乙琥胺或1-4-苯二氮䓬类药物联合使用时，其血清水平无显著变化。在原发性全身性癫痫中，丙戊酸钠与乙琥胺和氯巴占联合治疗后疗效最佳。
