Stefíková K, Spustová V, Sebeková K, Dzúrik R
Institute of Preventive and Clinical Medicine, Bratislava, Czech.
Mater Med Pol. 1992 Oct-Dec;24(4):215-6.
Insulin resistance (IR), probably a common pathway of atherosclerosis development in various diseases, was suggested to be related to magnesium (Mg) deficiency. The in vivo observations required an in vitro extension. The study was performed on isolated rat soleus muscle incubated in Ringer bicarbonate with/without Mg. Mg deficiency inhibited basal, insulin- and tolbutamide-stimulated glucose utilization. Insulin-stimulated glucose utilization was inhibited even in the case that insulin was given to rats before sacrifice. Similar inhibition of glucose utilization was found in Ca deficiency and the simultaneous lack of Mg had no additive effect. It is concluded that Mg deficiency inhibits glucose utilization at the level of Ca mediation of glucose transport regulation.
胰岛素抵抗（IR）可能是各种疾病中动脉粥样硬化发展的常见途径，据认为与镁（Mg）缺乏有关。体内观察结果需要进行体外扩展研究。本研究在分离的大鼠比目鱼肌上进行，将其置于含/不含镁的碳酸氢盐林格氏液中孵育。镁缺乏抑制基础状态、胰岛素和甲苯磺丁脲刺激的葡萄糖利用。即使在处死大鼠前给予胰岛素，胰岛素刺激的葡萄糖利用仍受到抑制。在钙缺乏时也发现了类似的葡萄糖利用抑制，同时缺乏镁并没有叠加效应。结论是，镁缺乏在葡萄糖转运调节的钙介导水平上抑制葡萄糖利用。
