Thonneau P, Quesnot S, Ducot B, Marchand S, Fignon A, Lansac J, Spira A
INSERM (Institut National de la Santé et de la Recherche Médicale), Unité No. 292, Santé Publique-Epidemiologie-Reproduction Humaine, Centre Hospitalier Universitaire de Bicêtre, France.
Hum Reprod. 1992 Jan;7(1):55-8. doi: 10.1093/oxfordjournals.humrep.a137557.
In order to evaluate male and female risk factors for infertility in a case-control study, we have compared all couples in a French administrative region consulting for primary or secondary infertility (of more than one year's duration) with couples in which the woman had given birth during the year of the study. For any one couple, a history of varicocele, male genital infections or testis damage multiplies the risk of primary infertility by a factor of 28, 3 and 4 respectively, and previous female infections (salpingitis) multiply the risk by 45. Similarly, a history of ectopic pregnancy, sexually transmitted diseases or salpingitis multiplies the risk of secondary infertility by a factor of 5, 4 and 7 respectively, and a history of varicocele multiplies this risk by 4.
为了在一项病例对照研究中评估男性和女性的不孕风险因素，我们将法国一个行政区内因原发性或继发性不孕（病程超过一年）前来咨询的所有夫妇，与研究当年女方已生育的夫妇进行了比较。对于任何一对夫妇，精索静脉曲张病史、男性生殖器感染或睾丸损伤会使原发性不孕风险分别增加28倍、3倍和4倍，而既往女性感染（输卵管炎）会使风险增加45倍。同样，宫外孕病史、性传播疾病或输卵管炎会使继发性不孕风险分别增加5倍、4倍和7倍，精索静脉曲张病史会使这种风险增加4倍。
