Bishop J F, Matthews J P, Yuen K, McGrath K, Wolf M M, Szer J
Peter MacCallum Cancer Institute, Alfred Hospital, Melbourne, Australia.
Transfus Med. 1992 Mar;2(1):35-41. doi: 10.1111/j.1365-3148.1992.tb00132.x.
The relationship between the 1 and 20 h post-transfusion platelet count and three parameters used to define refractory transfusions, namely the corrected increment (CI), platelet increment (PI), and percentage platelet recovery (%REC), was studied in 437 non-HLA matched platelet transfusions given to 102 patients with bone marrow failure. The percentage agreement between common definitions of refractoriness was calculated based on these parameters. As the maintenance of platelet counts above 20 x 10(9)/l is a relevant clinical goal for platelet support, the values of the CI, PI and %REC, which best corresponded to 1- and 20-h post-transfusion counts of 20 x 10(9)/l, were identified. A 1-h post-transfusion CI < 3 (PI < 7 x 10(9)/l or % REC < 8%) corresponded to clinically unsuccessful transfusions with a 1-h platelet count < 20 x 10(9)/l. A 1-h CI > or = 5.5 (PI > or = 12 x 10(9)/l or %REC > or = 14%) corresponded to clinically successful transfusions with a 20-h post-transfusion count of > or = 20 x 10/l. These data tie together the end points reported in the literature for defining refractory transfusions.
对102例骨髓衰竭患者进行了437次非HLA配型的血小板输注，研究了输血后1小时和20小时的血小板计数与用于定义难治性输血的三个参数之间的关系，这三个参数分别是校正增加值（CI）、血小板增加值（PI）和血小板回收率（%REC）。基于这些参数计算了难治性常见定义之间的百分比一致性。由于将血小板计数维持在20×10⁹/L以上是血小板支持的一个相关临床目标，因此确定了最符合输血后1小时和20小时血小板计数为20×10⁹/L的CI、PI和%REC值。输血后1小时CI<3（PI<7×10⁹/L或%REC<8%）对应于临床输血失败，即输血后1小时血小板计数<20×10⁹/L。输血后1小时CI≥5.5（PI≥12×10⁹/L或%REC≥14%）对应于临床输血成功，即输血后20小时血小板计数≥20×10⁹/L。这些数据将文献中报道的定义难治性输血的终点联系在一起。
