Leypoldt J K
Research Service, VA Medical Center, Salt Lake City, UT 84148.
Blood Purif. 1992;10(3-4):227-38. doi: 10.1159/000170049.
Pore models of peritoneal fluid and solute transport are reviewed and critiqued. Although several pore models of the peritoneal membrane have been previously formulated, a model containing three distinct pore sizes is required to accurately simulate both the molecular size dependence of solute transport and the time dependence of fluid transport during peritoneal dialysis in man. Nevertheless, certain observations from peritoneal dialysis experiments using animals do not agree with predictions from the three-pore model. These discrepancies suggest that the three-pore model of peritoneal transport based exclusively on capillary physiology is incomplete. Moreover, our inability to accurately estimate peritoneal reflection coefficients for small osmotic solutes questions whether lymph flow rates from the peritoneal cavity calculated using the three-pore model are reliable. Further experimental and theoretical studies are needed to obtain a better understanding of peritoneal transport physiology.
本文对腹膜液和溶质转运的孔模型进行了综述和批判。尽管此前已经提出了几种腹膜的孔模型，但需要一个包含三种不同孔径的模型来准确模拟人体腹膜透析过程中溶质转运的分子大小依赖性和液体转运的时间依赖性。然而，使用动物进行的腹膜透析实验的某些观察结果与三孔模型的预测不一致。这些差异表明，仅基于毛细血管生理学的腹膜转运三孔模型是不完整的。此外，我们无法准确估计小渗透溶质的腹膜反射系数，这使得使用三孔模型计算的腹腔淋巴流速是否可靠受到质疑。需要进一步的实验和理论研究，以更好地理解腹膜转运生理学。
