Yen S H, Liu W K
Department of Pathology, Albert Einstein College of Medicine, Bronx New York.
Chin J Physiol. 1992;35(4):357-66.
Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.
阿尔茨海默病的特征是神经原纤维病理改变，其中包含双螺旋丝（PHF）。这些异常丝由微管相关蛋白tau的一种修饰形式组成。这种修饰涉及磷酸化。在这篇综述中，我们总结了关于正常tau和PHF-tau之间差异的最新研究，尤其关注磷酸化的程度和位点。我们还讨论了可能参与PHF形成的机制。
