Kumar J
Department of Obstetrics & Gynaecology, National University of Singapore.
Ann Acad Med Singap. 1992 Jul;21(4):498-503.
The characteristics and regulation of oocyte maturation in the normal menstrual cycle is reviewed and the mechanisms by which ovarian hyperstimulation with exogenous gonadotrophins, used in assisted reproductive techniques, can disturb this process, is discussed. It is postulated that derangements induced in the maturation of oocytes in the hyperstimulated cycle result in the recovery of poor quality oocytes at egg-pickup which have a reduced potential to undergo normal fertilisation and subsequent embryonic development.
本文综述了正常月经周期中卵母细胞成熟的特征及调控，并讨论了辅助生殖技术中使用外源性促性腺激素进行卵巢过度刺激时扰乱这一过程的机制。据推测，在过度刺激周期中卵母细胞成熟过程中发生的紊乱，导致在取卵时回收的卵母细胞质量较差，其正常受精及随后胚胎发育的潜力降低。
