垂体腺苷酸环化酶激活多肽可刺激培养的大鼠嗜铬细胞分泌肾上腺素。
Pituitary adenylate cyclase activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline.
作者信息
Watanabe T, Masuo Y, Matsumoto H, Suzuki N, Ohtaki T, Masuda Y, Kitada C, Tsuda M, Fujino M
机构信息
Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd., Ibaraki, Japan.
出版信息
Biochem Biophys Res Commun. 1992 Jan 15;182(1):403-11. doi: 10.1016/s0006-291x(05)80159-7.
Pituitary adenylate cyclase activating polypeptide (PACAP) provoked the rat chromaffin cells to secrete adrenaline. Within 20 min, the amount of adrenaline secreted by PACAP (10(-8) M) was as much as that caused by acetylcholine (10(-4) M). PACAP, but not acetylcholine, induced a long-term (over 120 min) increase in secretion of adrenaline. PACAP also activated adenylate cyclase and elevated cytosolic Ca2+ concentration. Furthermore, we found immunoreactive PACAP and PACAP binding sites in the rat adrenal medulla. These results suggest that PACAP has an important role in stimulating secretion of adrenaline in the adrenal medulla.
垂体腺苷酸环化酶激活多肽（PACAP）可刺激大鼠嗜铬细胞分泌肾上腺素。在20分钟内，PACAP（10⁻⁸ M）分泌的肾上腺素量与乙酰胆碱（10⁻⁴ M）引起的量相当。PACAP可诱导肾上腺素分泌长期（超过120分钟）增加，而乙酰胆碱则不能。PACAP还可激活腺苷酸环化酶并提高胞质Ca²⁺浓度。此外，我们在大鼠肾上腺髓质中发现了免疫反应性PACAP和PACAP结合位点。这些结果表明，PACAP在刺激肾上腺髓质肾上腺素分泌中起重要作用。
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