与爱泼斯坦-巴尔病毒相关的皮肤血管中心性T细胞淋巴瘤
Cutaneous angiocentric T-cell lymphoma associated with Epstein-Barr virus.
作者信息
Tsai T F, Su I J, Lu Y C, Cheng A L, Yeh H P, Hsieh H C, Tien H F, Chen J S, Uen W C
机构信息
Department of Dermatology, National Taiwan University Hospital, Taipei, Republic of China.
出版信息
J Am Acad Dermatol. 1992 Jan;26(1):31-8. doi: 10.1016/0190-9622(92)70002-w.
BACKGROUND
Two unusual cases of cutaneous angiocentric T-cell lymphoma were found to be associated with Epstein-Barr virus infection.
OBJECTIVE
The objective was to study the clinical course and the response of the disease to conventional chemotherapy.
METHODS
Histologic specimens from both patients were studied. Clonal proliferation was assessed by Southern blot hybridization.
RESULTS
The disease in both patients was rapidly progressive and responded poorly to aggressive treatment. Biopsy specimens showed infiltration of atypical lymphoid cells with angiocentricity and angiodestruction, which probably resulted in the observed tissue necrosis. Clonal proliferation of Epstein-Barr virus DNA was detected in tissue from primary skin lesions and disseminated nasal lesions.
CONCLUSION
Epstein-Barr virus-associated angiocentric T-cell lymphoma in our patients was characterized by an aggressive course and resistance to conventional chemotherapy. A search for Epstein-Barr virus and the human T-lymphotropic virus should be performed in patients with atypical features of cutaneous T-cell lymphoma.
背景
发现两例不寻常的皮肤血管中心性T细胞淋巴瘤病例与爱泼斯坦-巴尔病毒感染有关。
目的
研究该疾病的临床病程以及对传统化疗的反应。
方法
对两名患者的组织学标本进行研究。通过Southern印迹杂交评估克隆增殖情况。
结果
两名患者的疾病均进展迅速，对积极治疗反应不佳。活检标本显示非典型淋巴细胞浸润，具有血管中心性和血管破坏，这可能导致了观察到的组织坏死。在原发性皮肤病变和弥漫性鼻部病变的组织中检测到爱泼斯坦-巴尔病毒DNA的克隆增殖。
结论
我们患者中的爱泼斯坦-巴尔病毒相关血管中心性T细胞淋巴瘤的特点是病程侵袭性强且对传统化疗耐药。对于具有皮肤T细胞淋巴瘤非典型特征的患者，应进行爱泼斯坦-巴尔病毒和人类嗜T淋巴细胞病毒的检测。
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