Nakahara H, Ishikawa T, Itabashi M, Hirota T
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Cancer. 1992 Feb 15;69(4):901-6. doi: 10.1002/1097-0142(19920215)69:4<901::aid-cncr2820690411>3.0.co;2-5.
A review of 2369 cases of resected primary colorectal carcinoma identified 15 cases of diffusely infiltrating colorectal carcinoma. Depending on the histologic pattern and extent, these cases were classified as linitis plastica (LP) type (seven cases) or lymphangiosis (LA) type (eight cases). The LP type consisted of poorly differentiated adenocarcinoma or signet ring cell carcinoma; it showed an annularly thickened and rigid bowel wall. The LA type consisted of moderately differentiated adenocarcinoma. The colon wall of the LA type was hemilaterally thickened at the mesenteric side. The prognosis was extremely poor for both types. The LP type mainly had peritoneal dissemination (70%), but the LA type frequently had distant metastasis (88%). Early diagnosis and curative operation are important for both types; however, the LA type also requires therapy for distant metastasis.
对2369例原发性结直肠癌切除病例的回顾发现了15例弥漫浸润性结直肠癌。根据组织学模式和范围，这些病例被分类为皮革胃（LP）型（7例）或淋巴管扩散（LA）型（8例）。LP型由低分化腺癌或印戒细胞癌组成；其表现为肠壁环形增厚且僵硬。LA型由中分化腺癌组成。LA型的结肠壁在肠系膜侧呈半侧增厚。两种类型的预后都极差。LP型主要有腹膜播散（70%），但LA型经常有远处转移（88%）。早期诊断和根治性手术对两种类型都很重要；然而，LA型还需要对远处转移进行治疗。
