异柠檬酸脱氢酶激酶/磷酸酶：选择性抑制磷酸酶活性的突变的鉴定。
Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity.
作者信息
Ikeda T P, Houtz E, LaPorte D C
机构信息
Department of Biochemistry, University of Minnesota, Minneapolis 55455-0347.
出版信息
J Bacteriol. 1992 Feb;174(4):1414-6. doi: 10.1128/jb.174.4.1414-1416.1992.
Abstract
Mutations in aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase, which selectively inhibit phosphatase activity have been isolated. These mutations yield amino acid substitutions within a 113-residue region of this 578-residue protein. These mutations may define a regulatory domain of this protein.
摘要
编码异柠檬酸脱氢酶激酶/磷酸酶的基因aceK发生了突变，这些突变可选择性抑制磷酸酶活性。这些突变导致该578个氨基酸残基的蛋白质中一个113个氨基酸残基区域内发生了氨基酸替换。这些突变可能界定了该蛋白质的一个调节结构域。
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