用铊-201进行无创性心肌闪烁造影的临床与实验研究（作者译）

[Clinical and experimental investigations with 201tl for noninvasive myocardial scintigraphy (author's transl)].

作者信息

Lichte H, Kriegel H, Sebening H, Hör G, Pabst H W, Dressler J, Sauer E

出版信息

Rofo. 1976 Mar;124(3):206-10. doi: 10.1055/s-0029-1230313.

Abstract

The biological distribution of 201Tl after intravenous injection was studied experimentally in 42 rats. It was found (see figure 1) that the kidneys showed the greatest affinity for 201Th, reaching an activity concentration of 6.6% per gramme of tissue, almost independently of time. Within the first 30 minutes of injection, myocardial activity exceeds that of the surrounding structures (10 min. p.i.: 4.24%/g; 30 min. p.i.: 2.58%/g). During this time the myocardium can be well demonstrated by "image processing". The relatively fast myocardial kinetics of 201Tl (half value time 33 minutes) make it necessary, strictly speaking, to use a scintillation camera. The clinical value of this method is illustrated by a number of case histories.

摘要

对42只大鼠进行实验研究，观察静脉注射后201铊的生物分布情况。结果发现（见图1），肾脏对201铊的亲和力最强，每克组织的放射性活度浓度达到6.6%，且几乎不受时间影响。注射后的前30分钟内，心肌放射性活度超过周围组织（注射后10分钟：4.24%/克；注射后30分钟：2.58%/克）。在此期间，通过“图像处理”可清晰显示心肌。严格来讲，201铊相对较快的心肌动力学（半衰期33分钟）使得有必要使用闪烁相机。若干病例说明了该方法的临床价值。