Kawano S, Tsuji S, Masuda E, Hayashi N, Tsujii M, Michida T, Kobayashi I, Fusamoto H, Kamada T
Department of Medicine, Osaka University Medical School.
Nihon Rinsho. 1992 Jan;50(1):33-8.
Although many authors reported that proton pump inhibitor showed mucosal protective activity, the precise mechanism is still unclear. In this study, we investigated the effect of proton pump inhibit on gastric mucosal hemodynamics, using a reflectance spectrophotometry system. The proton pump inhibitors had no effect on the gastric mucosal hemodynamics prior to the state of hemorrhagic shock state. However, during the hemorrhagic shock, proton pump inhibitors significantly inhibited the decrease in tissue oxygenation and significantly reduced ulcer formation. In conclusion, proton pump inhibitors maintained tissue oxygenation resulting in reduction of ulcer formation.
尽管许多作者报道质子泵抑制剂具有黏膜保护活性，但其确切机制仍不清楚。在本研究中，我们使用反射分光光度法系统研究了质子泵抑制剂对胃黏膜血流动力学的影响。在失血性休克状态之前，质子泵抑制剂对胃黏膜血流动力学没有影响。然而，在失血性休克期间，质子泵抑制剂显著抑制了组织氧合的降低，并显著减少了溃疡的形成。总之，质子泵抑制剂维持了组织氧合，从而减少了溃疡的形成。
