接受持续性非卧床腹膜透析治疗患者丙型肝炎病毒抗体的流行情况。

The prevalence of hepatitis C virus antibodies in patients treated with continuous ambulatory peritoneal dialysis.

作者信息

Huang C C, Wu M S, Lin D Y, Liaw Y F

机构信息

Division of Nephrology, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan, R.O.C.

出版信息

Perit Dial Int. 1992;12(1):31-3.

PMID:1311963

Abstract

OBJECTIVE

To assess the prevalence of anti-HCV (hepatitis C virus antibodies) in continuous ambulatory peritoneal dialysis (CAPD) patients and staff members.

DESIGN

Fifty-nine serum samples were collected and tested by an enzyme immunoassay for anti-HCV. Records and past history of blood transfusion and hemodialysis were reviewed. Results were analyzed using the Fisher's exact test.

SETTING

A medical college-operated teaching hospital.

PARTICIPANTS

Fifty-two patients and 7 staff members from the Chang Gung Memorial Hospital CAPD unit were studied.

RESULTS

Anti-HCV prevalence in patients and staff were 15.4% and 0%. A history of maintenance hemodialysis was associated with a higher prevalence of anti-HCV (33.3% versus 5.9% without hemodialysis, p = 0.015). The prevalence of anti-HCV did not increase with longer CAPD duration. Among those with an episode of hepatitis, higher prevalence of anti-HCV was observed (57.1% versus 8.9% without hepatitis, p = 0.0073).

CONCLUSION

HCV is an important agent of hepatitis in CAPD patients. The risk of HCV infection among CAPD staff members is negligible. CAPD offers better control of HCV infection among patients with end-stage renal failure.

摘要

目的

评估持续性非卧床腹膜透析（CAPD）患者及工作人员中抗丙型肝炎病毒（HCV）抗体的流行情况。

设计

收集59份血清样本，采用酶免疫法检测抗HCV。回顾输血和血液透析记录及既往史。结果采用Fisher精确检验进行分析。

地点

一所医学院附属医院。

参与者

研究对象为长庚纪念医院CAPD病房的52例患者和7名工作人员。

结果

患者和工作人员中抗HCV流行率分别为15.4%和0%。维持性血液透析史与抗HCV较高的流行率相关（有血液透析史者为33.3%，无血液透析史者为5.9%，p = 0.015）。抗HCV流行率并不随CAPD时间延长而增加。在有肝炎发作的患者中，抗HCV流行率更高（有肝炎发作史者为57.1%，无肝炎发作史者为8.9%，p = 0.0073）。