Miller L R, McCunniff A J, Randall M E
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Cancer. 1992 Apr 15;69(8):2166-71. doi: 10.1002/1097-0142(19920415)69:8<2166::aid-cncr2820690825>3.0.co;2-e.
The histogenesis of perianal Paget's disease is controversial. A clinical and pathologic study was done of a patient with a history of adenocarcinoma of the rectum for whom a subsequent diagnosis of perianal Paget's disease was the sole manifestation of recurrent rectal cancer. Immunohistochemical techniques were used to compare and contrast the original rectal adenocarcinoma with the subsequent perianal skin recurrence confined to the epidermis. Both the rectal adenocarcinoma and the Paget's cells were positive for cytokeratin, epithelial membrane antigen, B72.3, and carcinoembryonic antigen and negative for gross cystic disease fluid protein-15, Leu-M1, CA 125, and S-100 protein. These findings, their relevance to the histogenesis of perianal Paget's disease, and the possible clinical implications are discussed.
肛周佩吉特病的组织发生存在争议。对一名有直肠癌病史的患者进行了临床和病理研究，该患者随后被诊断为肛周佩吉特病，这是复发性直肠癌的唯一表现。采用免疫组织化学技术对原发性直肠腺癌与随后局限于表皮的肛周皮肤复发进行比较和对比。直肠腺癌和佩吉特细胞的细胞角蛋白、上皮膜抗原、B72.3和癌胚抗原均呈阳性，而大囊性病液蛋白-15、Leu-M1、CA 125和S-100蛋白均呈阴性。本文讨论了这些发现、它们与肛周佩吉特病组织发生的相关性以及可能的临床意义。
