Ampil F L, Abreo F
Department of Radiology, Louisiana State University School of Medicine, Shreveport.
South Med J. 1992 Mar;85(3):266-9. doi: 10.1097/00007611-199203000-00008.
Sixteen patients with spinal epidural compression by metastatic small-cell lung cancer were given radiotherapy for palliation. Lower limb motor deficit was the most prominent clinical manifestation. Neurologic dysfunction was commonly present for more than 48 hours before the diagnosis of compression. Median interval between diagnosis of lung cancer and epidural tumor was 8.5 months. Twelve percent of the patients survived for 1 year after diagnosis of epidural compression. Radiotherapy gave significant pain relief to eight (89%) of the symptomatic individuals. Among those whose status could be assessed, one third of the initially nonambulatory patients (n = 9) were able to walk again. Anal or bladder sphincter or sensory disturbance did not improve in four persons. Radiotherapy for spinal epidural compression in small-cell lung cancer, though not curative, is highly effective in the relief of pain and may ameliorate limb motor dysfunction in some patients.
16例因转移性小细胞肺癌导致脊髓硬膜外压迫的患者接受了姑息性放疗。下肢运动功能障碍是最突出的临床表现。在诊断出压迫之前，神经功能障碍通常已存在超过48小时。肺癌诊断与硬膜外肿瘤之间的中位间隔时间为8.5个月。12%的患者在硬膜外压迫诊断后存活了1年。放疗使8例（89%）有症状的患者疼痛得到显著缓解。在那些病情可评估的患者中，最初不能行走的患者中有三分之一（n = 9）能够再次行走。4例患者的肛门或膀胱括约肌功能或感觉障碍没有改善。小细胞肺癌脊髓硬膜外压迫的放疗虽然不能治愈，但在缓解疼痛方面非常有效，并且可能改善一些患者的肢体运动功能障碍。
