Sarlis N J, Chowdrey H S, Stephanou A, Lightman S L
Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, United Kingdom.
Endocrinology. 1992 Apr;130(4):1775-9. doi: 10.1210/endo.130.4.1312424.
Adjuvant-induced arthritis (AA) in Sprague-Dawley rats resulted in a chronic increase in plasma levels of ACTH and corticosterone (B). Joint inflammation became clinically apparent between days 12-15 after injection of adjuvant and reached a peak on day 21, after which time it subsided. In AA animals, plasma ACTH and B levels in the morning (0800-0900 h) on days 7, 8, 9, and 21 were significantly higher than those in control animals (day 0). The corresponding evening ACTH and B levels in AA animals were not significantly different from evening levels in the control animals. Adrenal weight in AA animals was increased on day 21, while thymic weight diminished gradually from days 7-21 postinjection. Development of AA was associated with activation of the hypothalamo-pituitary-adrenal axis, with increased morning ACTH and B levels and abolition of normal diurnal ACTH and B rhythms. This model of chronic inflammatory stress clearly activates the ACTH drive despite increased corticosteroid feedback in the morning, resulting overall in chronically increased B secretion.
佐剂诱导的斯普拉格-道利大鼠关节炎（AA）导致促肾上腺皮质激素（ACTH）和皮质酮（B）的血浆水平长期升高。在注射佐剂后第12至15天，关节炎症在临床上变得明显，并在第21天达到峰值，此后炎症消退。在患AA的动物中，第7、8、9和21天上午（08:00 - 09:00）的血浆ACTH和B水平显著高于对照动物（第0天）。AA动物相应的夜间ACTH和B水平与对照动物的夜间水平无显著差异。AA动物的肾上腺重量在第21天增加，而胸腺重量在注射后第7至21天逐渐减少。AA的发展与下丘脑-垂体-肾上腺轴的激活有关，表现为上午ACTH和B水平升高以及正常的ACTH和B昼夜节律消失。这种慢性炎症应激模型尽管早晨皮质类固醇反馈增加，但仍明显激活了ACTH驱动，总体导致B分泌长期增加。
