Sung R Y, Chan R C, Tam J S, Cheng A F, Murray H G
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T.
Epidemiol Infect. 1992 Feb;108(1):147-54. doi: 10.1017/s0950268800049591.
The epidemiological, clinical and virological features of 1220 children with acute bronchiolitis admitted to the Prince of Wales Hospital, Hong Kong, from 1985 to 1988 are reported. They accounted for 6.6% of total paediatric admissions and provided a case incidence of bronchiolitis requiring admission to hospital of approximately 21 per 1000 children 0-24 months of age. The clinical course and outcome was in general benign. The average hospital stay was 5 days and there were no deaths. Ten per cent of patients were repeatedly admitted to hospital with recurrent wheezing after discharge. Two infants developed bronchiolitis obliterans. Respiratory syncytial virus (RSV) was shown by direct immunofluorescence, virus culture and serology to be the commonest cause of acute bronchiolitis in Hong Kong. Other aetiological agents included parainfluenza and influenza viruses, adenoviruses, and Mycoplasma pneumoniae. In contrast to western countries, a seasonal variation of bronchiolitis was found with a peak incidence in the summer months. The significance of these observations is discussed.
报告了1985年至1988年期间香港威尔士亲王医院收治的1220例急性细支气管炎患儿的流行病学、临床和病毒学特征。这些患儿占儿科住院总数的6.6%，0至24个月龄儿童因细支气管炎需住院治疗的发病率约为每1000名儿童中有21例。临床病程和转归总体良好。平均住院时间为5天，无死亡病例。10%的患者出院后因反复喘息而再次入院。两名婴儿发生了闭塞性细支气管炎。通过直接免疫荧光、病毒培养和血清学检测显示，呼吸道合胞病毒（RSV）是香港急性细支气管炎最常见的病因。其他病原体包括副流感病毒和流感病毒、腺病毒以及肺炎支原体。与西方国家不同，细支气管炎存在季节性变化，夏季发病率最高。讨论了这些观察结果的意义。
