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Effects of GABA receptor stimulation on the release of [3H]GABA from slices of rat neostriatum.

作者信息

Meyer D K, Conzelmann U, Müller A

机构信息

Department of Pharmacology, University of Freiburg, F.R.G.

出版信息

Life Sci. 1992;50(13):931-7. doi: 10.1016/0024-3205(92)90170-t.

DOI:10.1016/0024-3205(92)90170-t
PMID:1312658
Abstract

Slices of rat neostriatum were incubated in Krebs-Henseleit medium. Modulation of [3H]GABA release by GABA agonists and antagonists was investigated. The GABAA receptor agonists muscimol (0.1 microM) and isoguvacine (5 microM) enhanced the stimulated release of [3H]GABA. The antagonists picrotoxin (1 microM) and bicuculline (50 microM) prevented the effects of the agonists. In the presence of naloxone (1 microM), which blocked the effects of enkephalinergic neurons within the slice preparation, muscimol (1 microM) no longer affected the release of [3H]GABA.

摘要

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