Krishnan G
Practitioner. 1976 Jan;216(1291):106-9.
In patients with facial acne good results were obtained by topical treatment with a 0-05 per cent solution of retinoic-acid (tretinoin) solution and with a 0-025 per cent solution. The improvement was judged by clinical assessment and by counts of comedones, papules and pustules before and after the 12-week trial. Side-effects such as irritation and erythema were less with the 0-025 per cent solution. The use of swabs impregnated with a constant volume of solution and sealed in a sachet proved to be a convenient method of application. In the placebo group, swabs impregnated with the solvent only showed virtually no effect on facial acne.
对面部痤疮患者，采用0.05%维甲酸（维甲酸）溶液和0.025%溶液进行局部治疗取得了良好效果。通过临床评估以及在12周试验前后对粉刺、丘疹和脓疱进行计数来判断改善情况。0.025%溶液的刺激性和红斑等副作用较少。使用浸渍有固定体积溶液并密封在小袋中的拭子被证明是一种方便的给药方法。在安慰剂组中，仅浸渍有溶剂的拭子对面部痤疮几乎没有效果。
