从慢性肾衰竭患者血清和尿液中分离出的葡萄糖利用抑制剂对大鼠肾皮质切片游离脂肪酸代谢的影响。
Effect of glucose utilization inhibitor isolated from the serum and urine of patients with chronic renal failure on the free fatty acid metabolism in rat kidney cortex slices.
作者信息
Chorváthová V, Dzúrik R, Ondreicka R, Ozdín L, Nemec R, Cerveń J
出版信息
Physiol Bohemoslov. 1976;25(2):123-7.
PMID:131346
Abstract
The authors studied interference by the inhibitor of glucose utilization with free fatty acid (FFA) metabolism in rat kidney cortex slices. They found that FFA uptake by the kidneys, their incorporation into triglycerides (TG) and oxidation to 14CO2 were lower when the inhibitor was present in the incubation medium. The findings show that the inhibitor, as well as inhibiting glucose utilization in various tissues, interferes directly with fat metabolism.
摘要
作者研究了葡萄糖利用抑制剂对大鼠肾皮质切片中游离脂肪酸（FFA）代谢的干扰作用。他们发现，当孵育培养基中存在该抑制剂时，肾脏对FFA的摄取、其掺入甘油三酯（TG）以及氧化为14CO2的水平均降低。这些发现表明，该抑制剂除了抑制各种组织中的葡萄糖利用外，还直接干扰脂肪代谢。
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