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从慢性肾衰竭患者血清和尿液中分离出的葡萄糖利用抑制剂对大鼠肾皮质切片游离脂肪酸代谢的影响。

Effect of glucose utilization inhibitor isolated from the serum and urine of patients with chronic renal failure on the free fatty acid metabolism in rat kidney cortex slices.

作者信息

Chorváthová V, Dzúrik R, Ondreicka R, Ozdín L, Nemec R, Cerveń J

出版信息

Physiol Bohemoslov. 1976;25(2):123-7.

PMID:131346
Abstract

The authors studied interference by the inhibitor of glucose utilization with free fatty acid (FFA) metabolism in rat kidney cortex slices. They found that FFA uptake by the kidneys, their incorporation into triglycerides (TG) and oxidation to 14CO2 were lower when the inhibitor was present in the incubation medium. The findings show that the inhibitor, as well as inhibiting glucose utilization in various tissues, interferes directly with fat metabolism.

摘要

作者研究了葡萄糖利用抑制剂对大鼠肾皮质切片中游离脂肪酸(FFA)代谢的干扰作用。他们发现,当孵育培养基中存在该抑制剂时,肾脏对FFA的摄取、其掺入甘油三酯(TG)以及氧化为14CO2的水平均降低。这些发现表明,该抑制剂除了抑制各种组织中的葡萄糖利用外,还直接干扰脂肪代谢。

相似文献

1
Effect of glucose utilization inhibitor isolated from the serum and urine of patients with chronic renal failure on the free fatty acid metabolism in rat kidney cortex slices.从慢性肾衰竭患者血清和尿液中分离出的葡萄糖利用抑制剂对大鼠肾皮质切片游离脂肪酸代谢的影响。
Physiol Bohemoslov. 1976;25(2):123-7.
2
Effect of glucose on the utilization of palmitate 1 14C by rat kidney cortex slices.葡萄糖对大鼠肾皮质切片利用棕榈酸1-14C的影响。
Physiol Bohemoslov. 1975;24(3):217-20.
3
Release of free fatty acids by the rat kidney.
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Relationship between free fatty acids and glucose uptake by rat kidney cortex slices.
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Metabolism of palmitate-1-14C in the tissues of rats with streptozotocin diabetes.链脲佐菌素诱导糖尿病大鼠组织中棕榈酸-1-14C的代谢
Physiol Bohemoslov. 1981;30(3):259-66.
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Intestinal metabolism of plasma free fatty acids. Intracellular compartmentation and mechanisms of control.血浆游离脂肪酸的肠道代谢。细胞内区室化及调控机制。
J Clin Invest. 1975 Apr;55(4):803-13. doi: 10.1172/JCI107991.
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Regulation of glucose metabolism by free fatty acid availability in septic and nonseptic rats.脓毒症和非脓毒症大鼠中游离脂肪酸可用性对葡萄糖代谢的调节作用
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[Aspects of glycolipid metabolism in chronic renal insufficiency: interference of oral glucose administration during and after dialysis with changes induced by short dialyses with glucose free dialysate].
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[Influence of indole-3-alkanecarboxylic acids on glucose utilization in rats].[吲哚-3-链烷羧酸对大鼠葡萄糖利用的影响]
Arzneimittelforschung. 1975 Jun;25(6):880-7.