钙离子、温度和蔗糖对离体大鼠右心室钾挛缩的影响。
The effect of Ca2+, temperature and sucrose upon potassium contracture of the isolated rat right ventricle.
作者信息
Slavicek J
出版信息
Physiol Bohemoslov. 1976;25(2):183-7.
Potassium (100 mM KC1) contracture of the isolated rat right ventricle was lower in Tyrode solution (37 mM Na) than on substituting sucrose (270 mM) for NaC1 and was biphasic in 70% of the experiments. As in slow (tonic) skeletal muscle, the maximum contracture value persisted as long as a raised KC1 concentration was maintained. Even after complete potassium depolarization it changed when Ca was altered. At 37 degrees C, the second phase of potassium contracture was higher than at 34 degrees C (p less than 0.01). The effect of K+ and Ca2+ was inhibited if the ions were added after adding sucrose to the Tyrode solution. Contracture of the rat ventricle resembled contracture of slow (tonic) skeletal muscle.
在分离的大鼠右心室中，与用蔗糖（270 mM）替代氯化钠相比，在台氏液（37 mM 钠）中，钾（100 mM 氯化钾）挛缩程度更低，且在70%的实验中呈双相性。与慢（紧张性）骨骼肌一样，只要维持升高的氯化钾浓度，最大挛缩值就会持续存在。即使在完全钾去极化后，当改变钙时它也会发生变化。在37℃时，钾挛缩的第二阶段高于34℃时（p<0.01）。如果在向台氏液中加入蔗糖后再添加离子，则钾离子和钙离子的作用会受到抑制。大鼠心室的挛缩类似于慢（紧张性）骨骼肌的挛缩。
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