Slootweg P J
Department of Pathology, University Hospital, Utrecht, The Netherlands.
J Oral Pathol Med. 1992 Feb;21(2):90-2. doi: 10.1111/j.1600-0714.1992.tb00986.x.
Two cases of melanotic neuroectodermal tumor of infancy (MNTI) contained highly cellular stromal areas consisting of spindle cells exhibiting mitotic activity. In one case, single spindle cells exhibited the same immunohistochemical profile as tumor cells forming part of the epithelial component. In the other case woven bone was formed in a dense fibroblastic stroma. These tumor parts were judged to be heterologous tissue elements that also may be observed in other kinds of neuroectodermal tumors and that reflect the potential of the neural crest to differentiate into various mesenchymal tissue types.
两例婴儿黑色素性神经外胚层肿瘤（MNTI）包含由具有有丝分裂活性的梭形细胞组成的高度细胞性间质区域。在其中一例中，单个梭形细胞表现出与构成上皮成分一部分的肿瘤细胞相同的免疫组化特征。在另一例中，致密的成纤维细胞间质中形成了编织骨。这些肿瘤部分被判定为异源性组织成分，在其他类型的神经外胚层肿瘤中也可能观察到，反映了神经嵴分化为各种间充质组织类型的潜能。
