Mapping antibody binding sites on protein antigens.
作者信息
Paterson Y
机构信息
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104-6076.
出版信息
Nature. 1992 Apr 2;356(6368):456-7. doi: 10.1038/356456a0.
DOI:10.1038/356456a0
PMID:1313552
Abstract
The large surfaces of protein antigens that interact with antibody-combining sites can be determined using deuterium-exchange labelling and two-dimensional 1H nuclear magnetic resonance (NMR). This technique may also be applied to other protein-protein interactions to identify key residues that contribute to the affinity.
摘要
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