Nakamura S, Takagi N, Kitoh K, Koshikawa T, Hayashi K, Yamamoto K, Suzuki H, Oyama A, Ueda R, Suchi T
Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Japan.
Acta Pathol Jpn. 1992 Feb;42(2):141-9. doi: 10.1111/j.1440-1827.1992.tb03090.x.
A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) which showed widespread involvement of the gastrointestinal tract is reported. A lymph node biopsy specimen showed the characteristic histological features of AILD. During the progression of the illness, lymphomatous lesions developed in the gastrointestinal tract, complicated by cytomegalovirus infection. A double immunoenzymatic study using a combination of Ki-67 antibody and antibodies against surface antigens demonstrated that CD3+, CD4+, and/or T-cell receptor (TCR) beta+ cells were predominant (67-68%) among the population of proliferating Ki-67% cells, rather than CD8+ or CD22+ cells. Clonal rearrangement of the TCR beta chain gene was also detected. These findings provide further evidence for the neoplastic nature of lesions of this type, and the diagnosis of peripheral T-cell lymphoma.
报告了一例血管免疫母细胞性淋巴结病伴蛋白异常血症（AILD），其表现为胃肠道广泛受累。淋巴结活检标本显示出AILD的特征性组织学特征。在疾病进展过程中，胃肠道出现淋巴瘤性病变，并伴有巨细胞病毒感染。使用Ki-67抗体与表面抗原抗体联合进行的双重免疫酶研究表明，在增殖的Ki-67%细胞群体中，CD3+、CD4+和/或T细胞受体（TCR）β+细胞占主导（67-68%），而非CD8+或CD22+细胞。还检测到TCRβ链基因的克隆重排。这些发现为这类病变的肿瘤性质以及外周T细胞淋巴瘤的诊断提供了进一步证据。
