Ward J C, Harris K W, Penny L A, Forget B G, Kitamura T, Winkelmann J C
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Exp Hematol. 1992 Mar;20(3):371-3.
Restriction endonuclease mapping demonstrates a 3' end deletion of one erythropoietin receptor (EpoR) gene in TF-1 cells, a human erythroleukemia cell line that overexpresses the EpoR and proliferates in response to erythropoietin (Epo). EpoR mRNA transcripts are highly abundant and normal in size. These findings raise interesting questions about the possible role of this EpoR gene abnormality in the pathogenesis of the erythroleukemia from which this cell line was derived. This is the first report of an abnormal human erythropoietin receptor gene.
限制性内切酶图谱分析表明，在TF-1细胞中，一种促红细胞生成素受体（EpoR）基因发生了3'端缺失。TF-1细胞是一种人类红白血病细胞系，它过度表达EpoR并在促红细胞生成素（Epo）刺激下增殖。EpoR mRNA转录本高度丰富且大小正常。这些发现引发了关于这种EpoR基因异常在该细胞系所源自的红白血病发病机制中可能作用的有趣问题。这是关于人类促红细胞生成素受体基因异常的首次报道。
